Nice View of CleanEx Exp : GSE1749C_DOC

[General] [References] [Expression data]

General information about the entry
Dataset code GSE1749C
Dataset Title Preimplantation mouse embryo development
Description Studies using low-resolution methods to assess gene expression during preimplantation mouse development indicate that changes in gene expression either precede or occur concomitantly with the major morphological transitions, that is, conversion of the oocyte to totipotent 2-cell blastomeres, compaction, and blastocyst formation. Using microarrays, we characterized global changes in gene expression and used Expression Analysis Systematic Explorer (EASE) to identify biological and molecular processes that accompany and likely underlie these transitions. The analysis confirmed previously described processes or events, but more important, EASE revealed new insights. Response to DNA damage and DNA repair genes are overrepresented in the oocyte compared to 1-cell through blastocyst stages and may reflect the oocyte's response to selective pressures to insure genomic integrity; fertilization results in changes in the transcript profile in the 1-cell embryo that are far greater than previously recognized; and genome activation during 2-cell stage may not be as global and promiscuous as previously proposed, but rather far more selective, with genes involved in transcription and RNA processing being preferentially expressed. These results validate this hypothesis-generating approach by identifying genes involved in critical biological processes that can be the subject of a more traditional hypothesis-driven approach..
Organism Mus musculus
Format Type Intensity
Affymetrix;MOE430B
Number of Experiments 20
Maximum log 10.028338250278
Minimum log -6.34610691273108
References
Original URL http://www.ncbi.nlm.nih.gov/projects/geo/query/acc.cgi?acc=GSE1749
Paper Reference Zeng F et al. Dev Biol. 2004 Aug 15;272(2):483-96.
MEDLINE Reference 15282163
Experiments
Experiment numberExperiment CodeExperiment Description
1GSE1749C_GSM22669Oocyte 1 MOE430B;src:preimplantation mouse embryo;development stage=oocyte;"; CrossRefs: GSE1749A_EX1 GSE1749B_EX1;
2GSE1749C_GSM22670Oocyte 2 MOE430B;src:preimplantation mouse embryo;development stage=oocyte;"; CrossRefs: GSE1749A_EX2 GSE1749B_EX2;
3GSE1749C_GSM22671Oocyte 3 MOE430B;src:preimplantation mouse embryo;development stage=oocyte;"; CrossRefs: GSE1749A_EX3 GSE1749B_EX3;
4GSE1749C_GSM22672Oocyte 4 MOE430B;src:preimplantation mouse embryo;development stage=oocyte;"; CrossRefs: GSE1749A_EX4 GSE1749B_EX4;
5GSE1749C_GSM226731-Cell 1 MOE430B;src:preimplantation mouse embryo;development stage=1-cell;"; CrossRefs: GSE1749A_EX5 GSE1749B_EX5;
6GSE1749C_GSM226741-Cell 2 MOE430B;src:preimplantation mouse embryo;development stage=1-cell;"; CrossRefs: GSE1749A_EX6 GSE1749B_EX6;
7GSE1749C_GSM226751-Cell 3 MOE430B;src:preimplantation mouse embryo;development stage=1-cell;"; CrossRefs: GSE1749A_EX7 GSE1749B_EX7;
8GSE1749C_GSM226761-Cell 4 MOE430B;src:preimplantation mouse embryo;development stage=1-cell;";
9GSE1749C_GSM226772-Cell 1 MOE430B;src:preimplantation mouse embryo;development stage=2-cell;"; CrossRefs: GSE1749A_EX8 GSE1749B_EX9;
10GSE1749C_GSM226782-Cell 2 MOE430B;src:preimplantation mouse embryo;development stage=2-cell;"; CrossRefs: GSE1749A_EX9 GSE1749B_EX10;
11GSE1749C_GSM226792-Cell 3 MOE430B;src:preimplantation mouse embryo;development stage=2-cell;"; CrossRefs: GSE1749A_EX10 GSE1749B_EX11;
12GSE1749C_GSM226802-Cell 4 MOE430B;src:preimplantation mouse embryo;development stage=2-cell;";
13GSE1749C_GSM226958-Cell 1 MOE430B;src:preimplantation mouse embryo;development stage=8-cell;"; CrossRefs: GSE1749A_EX11 GSE1749B_EX13;
14GSE1749C_GSM226968-Cell 2 MOE430B;src:preimplantation mouse embryo;development stage=8-cell;"; CrossRefs: GSE1749A_EX12 GSE1749B_EX14;
15GSE1749C_GSM226978-Cell 3 MOE430B;src:preimplantation mouse embryo;development stage=8-cell;"; CrossRefs: GSE1749A_EX13 GSE1749B_EX15;
16GSE1749C_GSM226988-Cell 4 MOE430B;src:preimplantation mouse embryo;development stage=8-cell;"; CrossRefs: GSE1749A_EX14 GSE1749B_EX16;
17GSE1749C_GSM22699Blastocyst 1 MOE430B;src:preimplantation mouse embryo;development stage=blastocyst;"; CrossRefs: GSE1749A_EX15 GSE1749B_EX17;
18GSE1749C_GSM22700Blastocyst 2 MOE430B;src:preimplantation mouse embryo;development stage=blastocyst;"; CrossRefs: GSE1749A_EX16 GSE1749B_EX18;
19GSE1749C_GSM22701Blastocyst 3 MOE430B;src:preimplantation mouse embryo;development stage=blastocyst;"; CrossRefs: GSE1749A_EX17 GSE1749B_EX19;
20GSE1749C_GSM22702Blastocyst 4 MOE430B;src:preimplantation mouse embryo;development stage=blastocyst;";